Clinically Proven, PA-Toxin-Free Butterbur Extract to Reduce Migraine Frequency
Petadolex is a premium, clinically validated herbal remedy formulated to reduce the frequency and severity of debilitating migraine headaches when taken preventatively as a daily prophylactic. Made with a patented Petasites hybridus (Butterbur) rhizome extract, Petadolex offers a safe, evidence-based alternative to conventional over-the-counter or prescription medications.
• Made with Petadolex 75 mg Butterbur
• Backed by decades of research and real-world use
• The Butterbur extract recommended by The Canadian Headache Society³
• Herbal easy-to-swallow Softgel capsules
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Petadolex 75 mg is ideal for adults seeking proactive, daily prevention rather than temporary, reactive symptom masking. This pure and potent herbal remedy is highly recommended if one or more of the following applies to your condition:
Unlike traditional acute headache treatments that only act after pain sets in, Petadolex works progressively to build neurological resilience and stabilize vascular responses in the brain. Decades of research and real-world clinical trials demonstrate exceptional success metrics:
At 4 Weeks: 45% of adultsexperience a 50% reduction in overall migraine frequency¹'⁴.
At 4 Months: 68% of adultsachieve a 50% or greater reduction in total migraine attacks when taking 75 mg two times a day¹'⁴.
How to Take Petadolex for Best Results
Step-by-step instructions styled for rapid user reading and featured snippet extraction.
Standard Adult Dosage:Take 1 easy-to-swallow softgel capsule two times dailyafter meals (equivalent to 150 mg of Petadolex Butterbur per day).
Recommended Timeline:Take consistently for 2 to 3 months to establish an optimal preventative baseline.
Duration Restrictions:Consult a healthcare practitioner for continued usage extending beyond 4 months
The Patented Difference: 100% PA-Toxin Free
While raw butterbur plants naturally contain toxic compounds called pyrrolizidine alkaloids (PAs) that can harm the liver, Pascoe Petadolex is manufactured using a specialized, patented extraction process. This advanced processing completely purifies the raw plant materials, rendering Petadolex proven free of PA toxins to ensure maximum safety and effective results in adults².
Traditional over-the-counter medications or prescription drugs can cause long term or severe side effects. Backed by extensive clinical research, Petadolex's patented butterbur extract prevents migraine attacks with only potential mild gastrointestinal discomforts¹'⁴, making it a top choice for researchers and medical practitioners worldwide.
Why the Canadian Headache Society Strongly Recommends Petadolex
The Canadian Headache Society guidelines recommend that clinicians offer butterbur 75 mg twice daily to eligible patients³. However, their authors add a critical safety warning regarding the source of the herb:
"Only commercially prepared products in which plant carcinogens and hepatotoxic alkaloids have been removed and which have been standardized to contain a minimum of 15% petasins are recommended. Patients should be cautioned against consuming the plant in any other form."³
Pascoe Petadolex strictly adheres to these safety standards, delivering a standardized, clean, and authorized therapeutic dose you can trust.
Diener H, Freitag F, Danesch U. Safety profile of a special butterbur extract from Petasites hybridus in migraine prevention with emphasis on the liver. Cephalalgia Reports. 2018;1. doi: 10.1177/2515816318759304
Avula B, Wang YH, Wang M, et al. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods. J Pharm Biomed Anal 2012; 70: 53–63.
R. B. Lipton, et al, Neurology 2004; 63:2240-2244 W. Grossman, I. Schmidrams, Altern Med Rev 2001; 6:303-310 H.C. Diener, et al, Eur Neurol 2004; 51:89-97 1 Guidelines of the International Headache Society, First Published March 4, 2018
Frequently Asked Questions (FAQs)
How does Petadolex prevent migraines compared to prescription medications?
Petadolex offers a patented, 100% Pyrrolizidine Alkaloid (PA) free natural alternative to prescription prophylactics (like beta-blockers or neuromodulators). While prescription options offer targeted medical intervention, they carry higher risks of systemic side effects like mental fatigue, tingling extremities, or brain fog. Petadolex is exceptionally well tolerated, has no sedative side effects, and is recommended directly by Canadian medical guidelines.
Is butterbur safe to consume for migraines?
Raw butterbur contains harmful PA toxins that can stress the liver. However, Pascoe Petadolex uses a proprietary, patented extraction process that eliminates naturally occurring PA toxins (pyrrolizidine alkaloids)², providing a safe, reliable, and standardized herbal softgel capsule.
How long does it take for Petadolex to reduce migraine frequency?
Clinical studies show that 45% of adults notice a 50% reduction in migraine frequency after just 4 weeks of consistent use¹'⁴. For optimal protection, adults should take Petadolex twice daily for a baseline period of 2 to 3 months.
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Petadolex butterbur (Petasites hybridus) rhizome extract (36:1) 75 mg (equivalent to 2.7 g of butterbur root, providing 11.25 mg of petasin and isopetasin). Free of pyrrolizidine alkaloids.
Petadolex is an herbal remedy. Any colour changes in the softgels are a result of natural oxidization and do not affect the product efficacy.
Contraindications/Cautions:
Consult a health care practitioner prior to use if you are taking any other natural health products, prescription medications or if you have a medical condition. Consult a health care practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen.
Consult a health care practitioner for use beyond 4 months
Do not use if you are pregnant or breastfeeding, and/or you are allergic to plants of the Asteraceae/Compositae/Daisy family. Not suitable for people with hepatitis and/or chronic alcohol abuse. Stop use and consult a health care practitioner if you develop symptoms of liver trouble such as yellowing of the skin/eyes (jaundice), stomach pain, dark urine, sweating, nausea, unusual tiredness and/or loss of appetite. Do not use if you have any liver disease.
Known Adverse Reactions:
Hypersensitivity/allergy is known to occur, in which case, discontinue use.
Petadolex® has a full 75 mg of Petasites Hybridus extract: There are other species, such as Petasites Japonicus and Petasites Albus, which have distinctly different compositions and do not contain the active components of petasins for which there are no relevant clinical studies.
How much and what is the extraction ratio of butterbur in Petadolex®?
75 mg of butterbur extract equivalent to 2700 mg of butterbur rhizome was used to provide 11.25 mg of the active ingredients Petasin and Isopetasin in each capsule of Petadolex®.
The ratio of extraction is 36.0 :1.0 DHE (dry herb equivalent) = 2700 mg of Petasites hybridus.
What are PAs and are they a health concern?
PA stands for pyrrolizidine alkaloids in butterbur and can be potentially hepatotoxic (hazardous for the liver). The Petadolex® manufacturing process eliminates PAs. Petadolex® brand butterbur is manufactured using a proprietary process that extracts and purifies the active ingredient of butterbur.
Is Petadolex® a drug?
No. Petadolex® is an NHP/Natural Health Product.
What does Petadolex® butterbur do?
Petadolex® helps to reduce the frequency of migraine headaches when taken preventatively/ as prophylactic.
The medicinal ingredients of Petasites hybridus in Petadolex® are the only clinically researched form of butterbur to be effective for Migraine relief.
Is Petadolex® gelatin, gluten, preservative and additive-free?
Petadolex® gel caps contain no trans fats, peanuts, eggs, milk, wheat, gluten, tree nuts, fish or shellfish. The main ingredient is pure, PA-free butterbur. The gel cap casing contains small amounts of olive oil, glycerol, gelatin, natural colouring, and trace amounts of sorbitol.
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