Petadolex 75 mg

Take Petadolex 75 mg daily for the best migraine relief

The best way to treat migraine headaches is to prevent them. Take Petadolex 75 mg to help reduce the frequency of migraine headaches when taken preventatively. 

Preventing migraine headaches with Petadolex butterbur is one of the best ways to reduce the severity and frequency of debilitating migraine attacks. Petadolex 75 mg is a pure, potent and proven herbal migraine remedy to help reduce the frequency of migraine headaches when taken daily. 

Formulated with the highest quality butterbur extract through a patented process, Petadolex 75 mg helps to reduce migraine severity and frequency with natural active ingredients, safely. Petadolex is proven free of PA toxins to ensure safe and effective results in adults.²

Reduce migraine headaches with the best butterbur supplement

Based on clinical trials, 68% of adults experience a reduction in attacks by 50% or more by using Petadolex 75 mg two times a day after 4 months.¹ʼ⁴ After 4 weeks, studies show 45% of adults have a reduction in migraine headaches by 50%.¹ʼ⁴

For best results, adults should take the small easy-to-swallow softgels two times daily for 2-3 months. 

Petadolex 75 mg is right for you if one or more of the following applies:

• You experience 2 to 3 migraine headaches per month
• Your migraine headaches last more than 48 hours
• Your migraine pain is described as unbearable
• You experience neurological symptoms such as visual disturbances

Butterbur - nature’s most powerful headache remedy

Petadolex 75 mg helps to safely reduce migraine frequency with natural active ingredients. Formulated with the highest quality butterbur extract through a patented extraction process, Petadolex is purified from butterbur’s natural PA toxins. Petadolex 75 mg is clinically studied and proven to reduce the frequency of migraine headaches in adults with a long history of use. 

When compared to other butterbur extracts, Petadolex does not contain the naturally occurring PA toxins found in butterbur plants.¹ʼ⁴ The proprietary extraction process removes PA toxins (pyrrolizidine alkaloids) to offer patients the safest and best supplements for migraines. 

Traditional treatments for migraines or cluster headaches such as over-the-counter medications or prescription drugs have the potential to cause long-term or severe side effects. Backed by clinical research and used by patients worldwide, Petadolex’s patented butterbur extract is proven to prevent migraine attacks with only potential mild gastrointestinal discomforts.¹ʼ⁴

This makes Petadolex 75 mg one of the best butterbur supplements used by researchers and practitioners for the treatment of headaches and migraine symptoms. 

The Canadian Headache Society strongly recommends butterbur Petasites.

The Canadian Headache Society authors recommend that clinicians offer butterbur 75 mg twice daily to eligible patients. The guidelines add the following caution: “Only commercially prepared products in which plant carcinogens and hepatotoxic alkaloids have been removed and which have been standardized to contain a minimum of 15% petasins are recommended. Patients should be cautioned against consuming the plant in any other form.”³

1. Diener H, Freitag F, Danesch U. Safety profile of a special butterbur extract from Petasites hybridus in migraine prevention with emphasis on the liver. Cephalalgia Reports. 2018;1. doi:10.1177/2515816318759304
2. Avula B, Wang YH, Wang M, et al. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods. J Pharm Biomed Anal 2012; 70: 53–63.
3. Canadian Headache Society Guideline for Migraine Prophylaxis; Volume 39 Number 2 (Supplement 2) March 2012
4. R. B. Lipton, et al, Neurology 2004; 63:2240-2244 W. Grossman, I. Schmidrams, Altern Med Rev 2001; 6:303-310 H.C. Diener, et al, Eur Neurol 2004; 51:89-97 1 Guidelines of the International Headache Society, First Published March 4, 2018

Medicinal ingredients:

1 Capsule contains:

Petadolex butterbur (Petasites hybridus) rhizome extract (36:1) 75 mg (equivalent to 2.7 g of butterbur root, providing 11.25 mg of petasin and isopetasin). Free of pyrrolizidine alkaloids.

Non-Medicinal Ingredients:

Medium-chain triglycerides, Gelatin, Glycerol, Sorbitol, Olive oil, Purified water, and Natural mixed carotenoids.

Dosage: 

Adults: Take 1 Capsule 2 times daily.

Petadolex is an herbal remedy.  Any colour changes in the softgels are a result of natural oxidization and do not affect the product efficacy. 

Contraindications/Cautions:

Consult a health care practitioner prior to use if you are taking any other natural health products, prescription medications or if you have a medical condition. Consult a health care practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen.

Consult a health care practitioner for use beyond 4 months 

Do not use if you are pregnant or breastfeeding, and/or you are allergic to plants of the Asteraceae/Compositae/Daisy family. Not suitable for people with hepatitis and/or chronic alcohol abuse. Stop use and consult a health care practitioner if you develop symptoms of liver trouble such as yellowing of the skin/eyes (jaundice), stomach pain, dark urine, sweating, nausea, unusual tiredness and/or loss of appetite. Do not use if you have any liver disease.

Known Adverse Reactions:

Hypersensitivity/allergy is known to occur, in which case, discontinue use.

Petadolex - List of Studies

Download Migraine Diary 2023

What are the medicinal ingredients of Petadolex®?

Petasin & Isopetasin

What is the butterbur species used in Petadolex®?

Petasites hybridus

Are all butterbur species the same for Migraines?

Petadolex® has a full 75 mg of Petasites Hybridus extract: There are other species, such as Petasites Japonicus and Petasites Albus, which have distinctly different compositions and do not contain the active components of petasins for which there are no relevant clinical studies.

How much and what is the extraction ratio of butterbur in Petadolex®?

75 mg of butterbur extract equivalent to 2700 mg of butterbur rhizome was used to provide 11.25 mg of the active ingredients Petasin and Isopetasin in each capsule of Petadolex®.

The ratio of extraction is 36.0 :1.0 DHE (dry herb equivalent) = 2700 mg of Petasites hybridus.

What are PAs and are they a health concern?

PA stands for pyrrolizidine alkaloids in butterbur and can be potentially hepatotoxic (hazardous for the liver). The Petadolex® manufacturing process eliminates PAs. Petadolex® brand butterbur is manufactured using a proprietary process that extracts and purifies the active ingredient of butterbur.

Is Petadolex® a drug?

No. Petadolex® is an NHP/Natural Health Product.

What does Petadolex® butterbur do?

Petadolex® helps to reduce the frequency of migraine headaches when taken preventatively/ as prophylactic.

The medicinal ingredients of Petasites hybridus in Petadolex® are the only clinically researched form of butterbur to be effective for Migraine relief.

Is Petadolex® gelatin, gluten, preservative and additive-free?

Petadolex® gel caps contain no trans fats, peanuts, eggs, milk, wheat, gluten, tree nuts, fish or shellfish. The main ingredient is pure, PA-free butterbur. The gel cap casing contains small amounts of olive oil, glycerol, gelatin, natural colouring, and trace amounts of sorbitol.